Acne has more moods than we can keep up with. Ranging from subtle, even delicate whiteheads to hot pink volcanos, breakouts can downright, “Alright, I’m canceling my weekend plans” beasts.
But why do some pimples seem to exist without us knowing and others provoke pain—even when we do our best to let them be?
The short answer is that usually bacteria are to blame. Understanding what precisely sets off painful breakouts and how to soothe skin is the first step in bringing balance back to your skin. After learning about the why, head to our guide on how to get rid of under the skin pimples so you can step outside feeling confident in your skin.

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Breakdown of the 2 Types of Acne
Myths abound about the causes of acne and the best ways to banish it (no thanks to viral internet-fueled skincare trends—side note: dermatologists deem the TikTok “potato hack” ineffective and inane) [1]. Because of this, some of us may have forgotten the basics behind acne.
Acne, or acne vulgaris, is officially recognized as a complication of the pilosebaceous unit, an internal system comprised of your [2]:
- Pores
- Sebaceous (or oil) glands
- Oil duct
Blackheads, pustules, and more types of comedones result from your hair follicles getting clogged with all sorts of minute materials we encounter simply by being alive—dirt, oil, dead skin cells, and bacteria, among them.
Those “moods” of acne emerge in a variety of ways. Sometimes, several types of acne can surface all at once [3]. But broadly speaking, dermatologists classify acne in one of two ways.
#1 Inflammatory Acne
- Papules – Papules can usually be self-identified by their texture and color. They’re typically hard and pink.
- Nodules – Unlike pimples with pus in their center, nodules develop deep below the skin and typically emerge as raised bumps. They may appear as either white, pink, red, or yellow.
- Pustules – Pustules can be recognized by the pus they often contain (or emit) and/or the presence of white or yellow heads.
- Cysts – Cysts are the largest manifestations of cystic acne. These appear as big, soft white or red bumps that are filled with fluid and “buried” beneath the skin. They’re generally considered the most challenging to manage with topical treatments. They may also be more likely to scar than other types of acne, particularly if you try to pop or squeeze them. Are acne scars permanent? They don’t have to be when treated properly.
Generally, inflammatory acne appears on your back, chest, shoulders, and face [5]. While it’s not contagious, whatever may be causing inflammatory acne (a topic we’ll look at below) can also yield breakouts in other parts of your body.
#2 Non-Inflammatory Acne
You may know them as blackheads—where the pore is blocked with dirt, acne-causing bacteria, or other gunk—but the top of the pore remains open. This is why blackheads are observed to be dark in color. Non-inflammatory acne may also present as whiteheads, which appear as raised white-colored bumps.
Why Do Some Pimples Hurt to Touch?
Painful acne usually falls into the category of inflammatory acne (most commonly, cysts and pustules). With inflammatory acne, the usual causes of acne vulgaris— dirt and oily skin—may be at play.
That said, bacteria can also contribute, if not trigger, painful pimples. Bacteria in the skin may instigate a synthesis of enzymes that break down skin cells and oils [6]. When this happens, your body triggers a flood of cells, like lipases and cytokines, to attack what it perceives as a foreign invader [7].
As a result, you may experience acne that is characterized by a slew of uncomfortable symptoms, among them:
- Redness
- Pus
- Swelling
- Tenderness
- Facial warmth [8]
- Stinging and burning
- Scaliness
- Raw or cracked areas that may bleed
- Skin thickening and/or blistering
- Pain
At its worst, acne-causing bacteria can also incite an infection deep within your skin that may become painful. In case you do end up giving in to the temptation to pop and squeeze, here’s what to do after popping a pimple.

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Factors That Can Aggravate Inflammatory Acne
Inflammatory acne is primarily caused by those things that can get trapped in your pores—old dead skin cells, oil, dirt, and, of course, bacteria. However, it’s believed that certain lifestyle habits and conditions may also provoke inflammatory acne, including:
- Diet – The Cleveland Clinic reports that inflammatory acne is more prevalent among people who consume large amounts of fat, sugar, and dairy products.
- Smoking – Studies indicate a direct link between smoking and acne, in part because it causes an uptick in oil production and a reduction in vitamin E [9].
- Touching your inflamed pimple – Just in case you need another reason to keep your hands off your face, The Cleveland Clinic reports that popping, squeezing, and poking at those non-inflammatory whiteheads and blackheads can precipitate painful, inflammatory acne. Picking at acne can also lead to: scarring, infection, pain, and damage to hair follicles and pores.
- High humidity – If you live in a steamy climate, you might also have a higher risk of inflammatory acne.
- Using the wrong moisturizer – We all have our favorite skincare products, but clinging to the wrong moisturizer for your skin and/or moisturizing excessively can also set off pustules, nodules, and more. This underscores the importance of using a personalized daily moisturizer with SPF that’s designed to support your unique skin.
- Aggressively scrubbing your face – If you spot a blemish like a whitehead or a blackhead, you may be tempted to scour your face clean. But this is an ineffective method for getting rid of them, and it can aggravate blemishes and lead to irritation.
How to Treat Painful Pimples
Acne that is achy, tender, or sore to the touch can be tremendously disruptive—even if you’ve committed to keeping your hands off the site of the offending painful pimple. Fortunately, there are a handful of key ingredients that may help to soothe inflammatory acne and promote healing.
Benzoyl Peroxide
- By eradicating bacteria and helping to calm swelling
- By encouraging pores to cast off oil and dead skin cells
As a bonus, BP may be beneficial for treating acne scars. This ingredient is available in a wide range of product types—gels, cleansers, and spot treatments included.
One word of caution: benzoyl peroxide can be incredibly drying for some people. It may not be the best option for your skin if your skin veers on the dry, temperamental, or sensitive side.
Topical Retinoids
Available in gels, ointments, and creams (among other products), they may be recommended in conjunction with antibiotics and benzoyl peroxide. Oral forms of retinoic acids, such as isotretinoin (once known as Accutane), require a prescription. While effective, topical retinoids and other acne treatments, can cause acne to worsen before it improves.
Oral or Topical Antibiotics
Antibiotics work by attacking the bacteria that may be at the root of painful acne and decreasing inflammation. Two of the most frequently prescribed oral antibiotics are:
- Tetracycline
- Doxycycline
- Minocycline
Hormonal Therapy
Surgery
In other cases, surgery may be recommended to treat acne scars. This usually occurs if your dermatologist suspects “stuff” has gotten caught inside your pores and can only be urged out with special tools and extraction methods. Cortisone injections are also used to reduce inflammation.
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Take Care Of Your Complexion With PROVEN Skincare
Whether it’s non-inflammatory or inflammatory, acne can be a pain—physically and literally. Fortunately, a variety of OTC and more intensive treatments are available to help pave the way toward skin that feels as healthy as it appears.
When you tend to your skin with a personalized PROVEN Skincare 3-step system, you nurture its well-being from the inside out. Our skincare quiz addresses everything we need to know about your complexion to curate a three-step regimen—whether it’s a night cream or a facial cleanser, each formula contains clean, clinically effective ingredients fine-tuned to you.
Get started today to nip acne in the bud and start making your way towards clearer, cared-for skin.